Preliminary program - topics. This will be updated according received applications



1. Genes and Bioinformatics: sequence comparison; gene finding; protein structure prediction; DNA and protein motif detection; gene expression profile clustering; and phylogenetic tree reconstruction sequence analysis - sequence evolution and homology; sequence alignment:
null model, fidelity, and statistical significance; large deviation theory; hidden Markov models and its applications.

2.RNA folding - RNA secondary structures: energetics, dynamic programming, thermodynamic properties; pseudo-knots and tertiary structures: natural RNA: phylogenetic method, thermodynamics, and kinetics;

3. Protein folding - introduction to protein structure classification: folds, domains;
experimental studies: folding kinetics, thermodynamic stability; theoretical studies of toy models: phase diagram, energy landscape, and kinetics;
ab initio simulation; stucture prediction, e.g., profiles/motifs, threading;

4. Genomics
intron/exon, splicing, and gene finding; transcription regulation, termination; DNA motif identification; RNA-protein interaction: alternative splicing, editing, degradation; RNA interference; chromosomal structure and organization;

5.Molecular networks - molecular interaction: protein-protein, receptor-ligand, antibody-antigen; protein networks, e.g., signal transduction, chemotaxis; gene networks: natural and synthetic; immune networks;

6. molecular evolution - molecular evolution in-vitro evolution: RNA and protein breeding, DNA computing; theoretical studies of RNA evolution: quasi-species, neutral network