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Preliminary
program - topics. This will be updated according received applications
1. Genes and Bioinformatics: sequence comparison; gene finding; protein
structure prediction; DNA and protein motif detection; gene expression
profile clustering; and phylogenetic tree reconstruction sequence analysis
- sequence evolution and homology; sequence alignment:
null model, fidelity, and statistical significance; large deviation theory;
hidden Markov models and its applications.
2.RNA folding - RNA secondary structures: energetics, dynamic programming,
thermodynamic properties; pseudo-knots and tertiary structures: natural
RNA: phylogenetic method, thermodynamics, and kinetics;
3. Protein folding - introduction to protein structure classification:
folds, domains;
experimental studies: folding kinetics, thermodynamic stability; theoretical
studies of toy models: phase diagram, energy landscape, and kinetics;
ab initio simulation; stucture prediction, e.g., profiles/motifs, threading;
4. Genomics
intron/exon, splicing, and gene finding; transcription regulation, termination;
DNA motif identification; RNA-protein interaction: alternative splicing,
editing, degradation; RNA interference; chromosomal structure and organization;
5.Molecular networks - molecular interaction: protein-protein, receptor-ligand,
antibody-antigen; protein networks, e.g., signal transduction, chemotaxis;
gene networks: natural and synthetic; immune networks;
6. molecular evolution - molecular evolution in-vitro evolution: RNA and
protein breeding, DNA computing; theoretical studies of RNA evolution:
quasi-species, neutral network
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